Bryan Johnson to Livestream "Most Quantified Psychedelic Experiment in History" with 28mg Psilocybin Dose

Tech entrepreneur Bryan Johnson, known for his rigorous "Project Blueprint" anti-aging regimen, announced on X (formerly Twitter) his plan to livestream a psilocybin experience on Sunday, November 30th, at 10 AM PST. This event, described by Johnson as "the most quantified psychedelic experiment in history," will involve consuming 5.24 grams of dried B+ strain psilocybin cubensis mushrooms, containing a lab-confirmed 28 milligrams of active psilocybin. This marks his second dose in a three-month protocol aimed at exploring psilocybin's potential longevity benefits.

Johnson's livestream will feature an extensive data collection, measuring 249 independent biomarkers through 29 vials of blood, brain scans, and multi-omics profiling including DNA, epigenetics, metabolism, and hormones. The goal is to determine the effect of the psychedelic on longevity, with Johnson stating, "The science suggests psilocybin may be a longevity therapy." He cited potential benefits such as extended lifespan in mice, preserved telomeres, reduced inflammation, and improved cognition.

The event is set to include notable guest appearances, with Grimes DJ'ing a live set, and psychedelic experts Hamilton Morris and venture capitalist Steve Jurvetson discussing psychedelics. Hamilton Morris is recognized for his journalistic and scientific research into psychoactive drugs, notably as the creator and director of the television series "Hamilton's Pharmacopeia." High-profile individuals like MrBeast, Naval Ravikant, Marc Benioff, and David Friedberg are expected to check in during the experience, which will be moderated by Kate Tolo and Ashlee Vance. Johnson emphasized that the session is medically supervised in a legal setting, cautioning against at-home attempts due to legal and health risks.

Project Blueprint, Johnson's overarching initiative, involves a meticulously controlled lifestyle to reverse biological aging, with an estimated annual cost of $2 million. His efforts have included a strict vegan diet, stem-cell therapies, and extensive medical monitoring, all in pursuit of biological rejuvenation. Johnson's previous experiments, such as plasma transfusions from his son, have also drawn significant media attention and scrutiny.

While Johnson's claims regarding psilocybin's longevity benefits are based on emerging research, scientific consensus on psychedelics as anti-aging therapies is still developing. Studies suggest psilocybin may reduce inflammation, promote neurogenesis, and improve cognitive function, but more comprehensive clinical trials are needed to fully understand its efficacy and safety for human longevity. Johnson's public self-experimentation aims to contribute to this data, albeit in a highly personalized and monitored context.