X-Therma

Overview

X-Therma is a biotechnology firm specializing in developing advanced biopreservation solutions for regenerative medicine and organ transplantation. Founded in 2014, the company is headquartered in Richmond, California. X-Therma has raised significant funding to support its innovative projects, including a notable $22.4 million in a Series B funding round completed in early 2024. The founders of X-Therma are Xiaoxi Wei, Ph.D., and Mark Kline, who have pioneered the development of a unique biomimetic biopreservation technology that mimics natural antifreeze molecules found in Arctic organisms.

Recent Developments

  • October 2024: X-Therma announced achieving GMP (Good Manufacturing Practice) commercial readiness for its flagship product XT-Thrive®, which is designed to significantly enhance cell and tissue preservation by inhibiting ice formation during sub-zero storage. (source)
  • March 2024: X-Therma closed a successful $22.4 million Series B funding round. This funding will accelerate the clinical and commercial development of key products in their pipeline, such as XT-Thrive®, XT-NoVoTM, and XT-ViVo® & TimeSeal® aimed at sectors like cell therapy and organ transplantation. (source)
  • January 2024: X-Therma received FDA acceptance of a Drug Master File (DMF) for its XT-Thrive® product, an essential step for commercialization and ensuring compliance with industry standards. (source)
  • 2023: In the past year, X-Therma has been recognized by the biopharma industry for its innovative approaches to organ preservation and its potential to significantly impact the availability and longevity of preserved organs for transplantation. X-Therma's technologies are seen as potential game-changers in extending organ viability beyond current time constraints. (source)

Company Information

AttributeInformation
Founding Date2014
HeadquartersRichmond, California
FoundersXiaoxi Wei, Ph.D., Mark Kline
RevenueNot publicly disclosed
ProfitsNot publicly disclosed
Key InvestorsUndisclosed investors in Series B funding
IndustryBiotechnology
Number of EmployeesApproximately 100 employees

Early History

X-Therma was founded in 2014 by Xiaoxi Wei, Ph.D., and Mark Kline. The company emerged from research focusing on antifreeze proteins found in Arctic species. These proteins inspired X-Therma's development of biomimetic molecules, referred to as peptoids, designed to prevent ice formation at low temperatures—a significant issue in cell and tissue preservation. Initial funding enabled the company to advance its biotechnological research and develop key products like XT-Thrive®, aimed at addressing unmet needs in organ preservation and transportation.

Company Profile and Achievements

X-Therma's core technology is centered around its biomimetic peptoids, which provide a novel approach to biopreservation, offering chemical stability and biocompatibility. These peptoids serve to inhibit ice formation, allowing for prolonged storage of biological materials under sub-zero temperatures without compromising their integrity.

  • 2014: Foundation of X-Therma with focus on leveraging antifreeze protein research to develop new preservation technologies.
  • 2021: Completion of an oversubscribed Series A funding round, allowing expansion of research and development.
  • 2023: FDA accepts Drug Master File for XT-Thrive®, confirming that X-Therma’s technology meets critical safety and efficacy standards.
  • 2024: Series B funding raised $22.4 million, facilitating the expansion of clinical trials and potential market entry for their biopreservation products.

X-Therma aims to revolutionize organ transplantation by extending the preservation time window, enhancing transportation logistics, and increasing the availability of viable organs for transplant. Its technologies are set to play a crucial role in the development of regenerative medicine therapies.

Current Operations and Market Position

Currently, X-Therma is focused on finalizing its flagship products' development to facilitate widespread clinical and commercial application. The company's unique position in the biopreservation space provides it a competitive edge, especially in the burgeoning market of regenerative medicine and cell therapy.

The successful integration of its biopreservation technology into existing clinical protocols showcases a significant potential for decreasing global organ shortages, improving organ transportation regimens, and enabling advancements in tissue engineering.

Conclusion

X-Therma stands as a pioneering entity within the biotechnology industry, particularly in the fields of regenerative medicine and organ preservation. The company's innovative approach employs biomimetic molecules to overcome time constraints in biological preservation, offering promising solutions for critical health challenges. With recent financial backing and FDA regulatory milestones, X-Therma is poised to expand its influence in the biotechnology space, with a vision for transforming healthcare delivery in organ transplantation and regenerative therapies. Looking ahead, X-Therma's dedication to innovation and capability to resolve complex preservation issues will likely facilitate broader contributions to healthcare globally.

References

  1. PR Newswire Announcement
  2. Bio.News Pipeline Announcement
  3. X-Therma Company Website
  4. Business Wire Series B Funding
  5. Crunchbase Profile
  6. Street Insider News
  7. LinkedIn Profile
  8. X-Therma Newsroom
  9. BIO Asia Pacific