0.1% Pterostilbene Emulsion Delivers Significant Anti-Aging Results in 28-Day Clinical Trial

A recent 28-day clinical trial involving a 0.1% pterostilbene facial emulsion has demonstrated significant anti-aging benefits, including firmer, more elastic skin and reduced visible wrinkles. The findings, which involved 31 participants aged 32–53, suggest a notable advancement in skincare technology. Dr. Singularity, a commentator on scientific developments, made a bold prediction in a recent social media post, stating, > "Soon, everyone will look young and beautiful a world filled with people who appear ~25 years old. People are not ready."

The clinical trial, conducted using a double-blind, split-face design, rigorously compared the effects of the pterostilbene emulsion against a placebo. At the conclusion of the 28-day period, the side of the face treated with pterostilbene exhibited statistically significant improvements across multiple metrics. Participants reported enhanced skin elasticity and firmness, alongside a reduction in visible wrinkles, including forehead, undereye, and Crow's feet, and smaller looking pores, according to the published study in ScienceDirect.

Further microscopic and imaging analyses corroborated these external observations, revealing that the 0.1% pterostilbene emulsion actively increased the thickness of the epidermis. It also boosted the amount of collagen and elastic fibers, which are crucial structural components supporting skin firmness and resilience. These internal cellular changes underscore pterostilbene's potent anti-aging efficacy, providing a scientific basis for the observed improvements.

Pterostilbene, a natural polyphenolic compound found in sources such as blueberries and Pterocarpus marsupium, is increasingly recognized for its promising role in skincare. Research indicates that this stilbene possesses higher bioavailability and improved stability compared to its analogue, resveratrol, making it a potentially superior active ingredient in cosmetic formulations. Its enhanced lipophilic properties contribute to greater cellular uptake and prolonged efficacy, as highlighted in a scoping review published in PMC.

The positive outcomes of this clinical trial underscore pterostilbene's value as an active ingredient in anti-aging cosmetics, offering a new perspective on natural compounds in the skincare industry. Zhiyuan Chen, Founder of Guangzhou Luanying Cosmetics Co., Ltd., noted that the results "remarkably improved skin elasticity, firmness, and reduced wrinkles," as reported by ScienceDaily. While these immediate results are promising, researchers suggest that longer study periods are needed to fully understand the long-term impact and broader implications of pterostilbene on skin aging.